Micro e nanoplásticos no sistema cardiovascular humano: evidências sobre presença, aterosclerose e desfechos cardiovasculares

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DOI:

https://doi.org/10.47224/revistamaster.v11i21.862

Keywords:

Microplastics, atherosclerosis, major adverse cardiovascular events, integrative review

Abstract

Introduction: Global plastic production exceeds 400 million tons annually, generating micro- and nanoplastics (MNPs) that contaminate food, water, and air (Zhu et al., 2022; Irfan et al., 2024; Prattichizzo et al., 2024). Recent evidence has detected these particles in human cardiovascular tissues, suggesting their role as an emerging cardiovascular risk factor (Marfella et al., 2024; Liu et al., 2024; Cui et al., 2025). Objective: To synthesize clinical evidence on the detection of MNPs in the human body and their associations with cardiovascular outcomes. Methods: An integrative review was conducted using PubMed and Scopus databases (2020–2025), including studies in English, Portuguese, and Spanish, based on descriptors related to microplastics, atherosclerosis, cardiovascular outcomes, and biomonitoring (Mendes, Silveira & Galvão, 2008). Nine studies were included: two prospective cohorts, three cross-sectional studies, and four reviews. Results: All five original studies detected MNPs in cardiovascular samples, with significantly higher concentrations in atherosclerotic tissues (Marfella et al., 2024; Liu et al., 2024; Massie et al., 2025; Cui et al., 2025; Clark et al., 2025). Polyethylene, polyvinyl chloride, polyethylene terephthalate, and polypropylene were the most frequent polymers. Marfella et al.. (2024) reported a 4.53-fold higher risk of major adverse cardiovascular events in patients with MNPs in carotid plaques. Zhang et al. (2025) confirmed an association between coronary PVC and MACE. Proposed mechanisms include oxidative stress, chronic inflammation, endothelial dysfunction, and thrombogenesis. Conclusion: MNPs represent a biologically plausible cardiovascular risk factor; however, causality remains unestablished, highlighting the need for longitudinal studies and analytical standardization.  

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References

CLARK, R. et al. Carotid plaque microplastics are associated with clinical symptoms and mesenchymal stem cell-macrophage immunomodulatory effects. Arteriosclerosis, Thrombosis, and Vascular Biology, v. 45, suppl. 1, p. Tu0030, 2025. DOI: https://doi.org/10.1161/atv.45.suppl_1.tu0030

CUI, C. et al. Tissue-specific distribution of microplastics in human blood and carotid plaques: a paired sample analysis. Environment International, v. 199, p. 109743, 2025. DOI: https://doi.org/10.1016/j.envint.2025.109743

DI GUARDO, G. Micro-nanoplastics as potential carriers of dioxins and Toxoplasma gondii in patients with carotid atheromas. Parasitologia, v. 4, n. 2, p. 9, 2024. DOI: https://doi.org/10.3390/parasitologia4020009

DUGGAL, B.; KUMAR, G. Cardiotoxicity of microplastics: an emerging cardiovascular risk factor. Current Cardiology Reviews, v. 21, 2025. DOI: https://doi.org/10.2174/011573403X366030250404105925

GOLDSWORTHY, A. et al. Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review. Journal of Exposure Science and Environmental Epidemiology, 2025. DOI: https://doi.org/10.1038/s41370-025-00766-2

IRFAN, H. et al. Microplastics and nanoplastics: emerging threats to cardiovascular health: a comprehensive review. Annals of Medicine and Surgery, v. 86, n. 12, p. 7369-7382, 2024. DOI: https://doi.org/10.1097/MS9.0000000000002831

LIU, S. et al. Microplastics in three types of human arteries detected by pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS). Journal of Hazardous Materials, v. 469, p. 133855, 2024. DOI: https://doi.org/10.1016/j.jhazmat.2024.133855

LIUZZO, G.; PATRONO, C. Plastic particles in carotid plaques: inactive debris or predictors of cardiovascular events? European Heart Journal, v. 45, n. 27, p. 2375-2377, 2024. DOI: https://doi.org/10.1093/eurheartj/ehae307

MARFELLA, R. et al. Microplastics and nanoplastics in atheromas and cardiovascular events. New England Journal of Medicine, v. 390, n. 10, p. 900-910, 2024. DOI: https://doi.org/10.1056/NEJMoa2309822

MASSIE, P. L. et al. Micro- and nanoplastics are elevated in femoral atherosclerotic plaques compared with undiseased arteries. JVS-Vascular Science, v. 6, p. 100393, 2025. DOI: https://doi.org/10.1016/j.jvssci.2025.100393

MENDES, K. D. S.; SILVEIRA, R. C. C. P.; GALVAO, C. M. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto – Enfermagem, v. 17, n. 4, p. 758-764, 2008. DOI: https://doi.org/10.1590/S0104-07072008000400018

MOORTHY, S. et al. Evidence, mechanisms, and clinical implications of microplastics and nanoplastics as emerging cardiovascular risk factors: a narrative review. Cureus, v. 17, n. 3, p. e85696, 2025. DOI: https://doi.org/10.7759/cureus.85696

PRATTICHIZZO, F. et al. Micro-nanoplastics and cardiovascular diseases: evidence and perspectives. European Heart Journal, v. 45, n. 38, p. 4099-4110, 2024. DOI: https://doi.org/10.1093/eurheartj/ehae552

ZHANG, Y. et al. Microplastics and nanoplastics increase major adverse cardiac events in patients with myocardial infarction. Journal of Hazardous Materials, v. 489, p. 137624, 2025. DOI: https://doi.org/10.1016/j.jhazmat.2025.137624

ZHENG, H. et al. Microplastics and nanoplastics in cardiovascular disease: a narrative review with worrying links. Frontiers in Toxicology, v. 6, p. 1479292, 2024. DOI: https://doi.org/10.3389/ftox.2024.1479292

ZHU, X. et al. Micro- and nanoplastics: a new cardiovascular risk factor? Environment International, v. 171, p. 107662, 2022. DOI: https://doi.org/10.1016/j.envint.2022.107662

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Published

2026-08-26

How to Cite

RODRIGUES DA CUNHA E PAULA, Isabella; SOUSA ANGELOTTI, João Victor; GARCIA E SOUZA, Vitória; RODRIGUES DE MESQUITA, Ana Lygia; OLIVEIRA, Rosana de Cássia. Micro e nanoplásticos no sistema cardiovascular humano: evidências sobre presença, aterosclerose e desfechos cardiovasculares. Revista Master - Ensino, Pesquisa e Extensão, [S. l.], v. 11, n. 21, 2026. DOI: 10.47224/revistamaster.v11i21.862. Disponível em: https://revistamaster.imepac.edu.br/RM/article/view/862. Acesso em: 27 aug. 2026.

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Vol. 11 No. 21 (2026): Revista Master - Ensino, Pesquisa e Extensão

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Artigos de revisão

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