Como o SARS-CoV-2 afeta a memória do paciente pós COVID-19: uma revisão integrativa
DOI:
https://doi.org/10.47224/revistamaster.v7i14.352Keywords:
COVID-19, Amnesia, Memory, PrevalenceAbstract
Introduction: The coronavirus disease 2019 (COVID-19) is caused by the new coronavirus SARS-CoV-2, through analyzes it was observed that the virus has neurotropism, capable of infecting cortical and hypothalamic regions, causing short-term memory loss and long-term in some patients. Objective: The study intended to clarify how SARS-CoV-2 affects patient memory after COVID-19 infection. Methodology: This is an integrative literature review that proposes to analyze and explain the topic through the existing scientific production. Results: The occurrence of neurological manifestations, including physical changes, such as strokes, and behavioral changes, such as memory loss, is proven. Reports claim that large numbers of people who have recovered from COVID-19 do not feel like they did before the infection, including short-term memory loss, confusion, and an inability to focus. Amnesia is one of the most frequent signs identified in patients with persistent symptoms related to COVID-19. Conclusion: Through the integrative literature review, it was understood that the SARS-CoV-2 virus has pathophysiological mechanisms to reach the CNS, indirectly, with inflammatory cytokines, and directly with the action of the virus or both. Causing harmful consequences to the CNS, such as short- and long-term memory loss and cognitive deficit. More studies are needed to associate the actions of SARS-CoV-2 in the CNS and memory loss, since it is a current disease and is still in the discovery phase.
Downloads
References
ADHIKARI, N.; TANSEY, C. M.; McANDREWS, M. P. et al. Self-reported depressive symptoms and memory complaints in survivors five years after ARDS. Chest, v. 140, p. 1484–1493, 2011. DOI: 10.1378/chest.11-1667. Disponível em: https://pubmed.ncbi.nlm.nih.gov/21998261/. Acesso em: 31 out. 2022. DOI: https://doi.org/10.1378/chest.11-1667
AIYEGBUSI, O. L.; HUGHES, S. E.; Turner, G. et al. Symptoms, complications and management of long COVID: a review. Journal of the Royal Society of Medicine, v. 114, p. 428-442, 2021. DOI: 10.1177/01410768211032850. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34265229/. Acesso em: 21 out. 2022. DOI: https://doi.org/10.1177/01410768211032850
ARABI, Y. M.; HARTHI, A., HUSSEIN, J. et al. Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV). Infection, v. 43, p. 495–501, 2015. DOI: 10.1007/s15010-015-0720-y. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25600929/. Acesso em: 24 out. 2022. DOI: https://doi.org/10.1007/s15010-015-0720-y
BECKER, J. H.; LIN, J. J.; DOEMBERG, M. et al. Assessment of Cognitive Function in Patients After COVID-19 Infection. JAMA Network Open, v. 4, 2021. DOI: 10.1001/jamanetworkopen.2021.30645. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34677597/. Acesso em: 31 out. 2022. DOI: https://doi.org/10.1001/jamanetworkopen.2021.30645
BOHMWALD, K.; GÁLVEZ, N.; RÍOS, M.; KALERGIS, A. M. Neurologic Alterations Due to Respiratory Virus Infections. Frontiers in cellular neuroscience, v. 12, 2018. DOI: 10.3389/fncel.2018.00386. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30416428/. Acesso em: 22 out. 2022. DOI: https://doi.org/10.3389/fncel.2018.00386
CAROD-ARTAL, F. J. Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved. Revista de neurologia, v. 72, p. 384–396, 2021. DOI: 10.33588/rn.7211.2021230. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34042167/. Acesso em: 21 out. 2022 DOI: https://doi.org/10.33588/rn.7211.2021230
CIACCIO, M., LO SASSO, B., SCAZZONE, C., GAMBINO, C. M. et al. COVID-19 and Alzheimer's Disease. Brain Sciences, v. 11, 2021. DOI: 10.3390/brainsci11030305. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33673697/. Acesso em: 21 out. 2022. DOI: https://doi.org/10.3390/brainsci11030305
COWAN, N. What are the differences between long-term, short-term, and working memory?. Progress In Brain Research, v. 169, p. 323–338, 2008. DOI: 10.1016/S0079-6123(07)00020-9. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657600/. Acesso em: 22 out. 2022. DOI: https://doi.org/10.1016/S0079-6123(07)00020-9
CUCCHIARA, B. L.; KORALNIK, I. J. COVID-19: Neurologic complications and management of neurologic conditions. UpToDate, 2021. Disponível em: https://www.uptodate.com/contents/covid-19-neurologic-complications-and-management-of-neurologic-conditions. Acesso em: 22 out. 2022.
CUCINOTTA, D.; VANELLI, M. WHO Declares COVID-19 a Pandemic. Acta Biomedica Atenei Parmensis, [S. l.], v. 91, n. 1, p. 157–160, 2020. DOI: 10.23750/abm.v91i1.9397. Disponível em: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/9397. Acesso em: 11 out. 2022.
DAHM, T.; RUDOLPH, H.; SCHWERK, C. et al. Neuroinvasion and Inflammation in Viral Central Nervous System Infections. Mediators of Inflammation, v. 2016, 2016. DOI: 10.1155/2016/8562805. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27313404/. Acesso em: 24 out. 2022. DOI: https://doi.org/10.1155/2016/8562805
DESFORGES, M.; LE COUPANEC, A.; BRISON, E. et al. Neuroinvasive and neurotropic human respiratory coronaviruses: potential neurovirulent agents in humans. Advances In Experimental Medicine And Biology, v. 807, p. 75-96, 2014. DOI: 10.1007/978-81-322-1777-0_6. Disponível em: https://pubmed.ncbi.nlm.nih.gov/24619619/. Acesso em: 22 out. 2022. DOI: https://doi.org/10.1007/978-81-322-1777-0_6
DIAS, B. C.; EVANGELISTA, L. C. R.; MAZER, G. H. C. et al. Alterações cognitivas e de memória na COVID-19: Revisão Integrativa da Literatura. New Trends in Qualitative Research, v. 13, p. e708, 2022. DOI: 10.36367/ntqr.13.2022.e708. Disponível em: https://www.publi.ludomedia.org/index.php/ntqr/article/view/708. Acesso em: 17 out. 2022.
ELLUL, M. A.; BENJAMIN, L.; SINGH, B. et al. Neurological associations of COVID-19. The Lancet. Neurology, v. 19, p. 767–783, 2020. DOI: 10.1016/S1474-4422(20)30221-0. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32622375/. Acesso em: 01 nov. 2022. DOI: https://doi.org/10.1016/S1474-4422(20)30221-0
FAZZINI, E.; FLEMING, J.; FAHN, S. Cerebrospinal fluid antibodies to coronavirus in patients with Parkinson's disease. Movement Disorders: Official Journal of the Movement Disorder Society, v. 7, p. 153–158, 1992. DOI: 10.1002/mds.870070210. Disponível em: https://pubmed.ncbi.nlm.nih.gov/1316552/. Acesso em: 24 out. 2022. DOI: https://doi.org/10.1002/mds.870070210
FERRUCCI, R.; DINI, M.; GROPPO, E. et al. Long-Lasting Cognitive Abnormalities after COVID-19. Brain Sciences, v. 11, 2021. DOI: 10.3390/brainsci11020235. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33668456/. Acesso em: 22 out. 2022. DOI: https://doi.org/10.3390/brainsci11020235
GANDHI, S.; SRIVASTAVA, A. K.; RAY, U., TRIPATHI, P. P. Is the Collapse of the Respiratory Center in the Brain Responsible for Respiratory Breakdown in COVID-19 Patients?. ACS Chemical Neuroscience, v. 11, p. 1379–1381, 2020. DOI: 10.1021/acschemneuro.0c00217. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32348111/. Acesso em: 24 out. 2022. DOI: https://doi.org/10.1021/acschemneuro.0c00217
GUESSER, V. M.; PAIVA, K. M.; BARROS, V. N. et al. Alterações cognitivas decorrentes da COVID-19: uma revisão sistemática. Revista Neurociências, [S. l.], v. 30, p. 1–26, 2022. DOI: 10.34024/rnc.2022.v30.13848. Disponível em: https://periodicos.unifesp.br/index.php/neurociencias/article/view/13848. Acesso em: 22 out. 2022. DOI: https://doi.org/10.34024/rnc.2022.v30.13848
HELMS, J.; KREMER, S.; MERDJI, H. et al. Neurologic Features in Severe SARS-CoV-2 Infection. The New England Journal Of Medicine, v. 382, p. 2268–2270, 2020. DOI: 10.1056/NEJMc2008597. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32294339/. Acesso em: 31 out. 2022. DOI: https://doi.org/10.1056/NEJMc2008597
HOPKINS, R. O.; GALE, S. D.; WEAVER, L. K. Brain atrophy and cognitive impairment in survivors of Acute Respiratory Distress Syndrome. Brain Injury, v. 20, p. 263–271, 2006. DOI:10.1080/02699050500488199. Disponível em: https://pubmed.ncbi.nlm.nih.gov/16537268/. Acesso em: 24 out. 2022. DOI: https://doi.org/10.1080/02699050500488199
HOPKINS, R. O.; WEAVER, L. K.; COLLINGRIDGE, D. et al. Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, v. 171, p. 340–347, 2005. DOI: 10.1164/rccm.200406-763OC. Disponível em: https://pubmed.ncbi.nlm.nih.gov/15542793/. Acesso em: 24 out. 2022. DOI: https://doi.org/10.1164/rccm.200406-763OC
HOSEY, M. M.; NEEDHAM, D. M. Survivorship after COVID-19 ICU stay. Nature Reviews. Disease Primers, v. 6, 2020. DOI: 10.1038/s41572-020-0201-1. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32669623/. Acesso em: 17 out. 2022. DOI: https://doi.org/10.1038/s41572-020-0201-1
JAYWANT, A.; VANDERLIND, W. M.; ALEXOPOULOS, G. S. et al. Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology, v. 46, p. 2235-2240, 2021. DOI: 10.1038/s41386-021-00978-8. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33589778/. Acesso em: 21 out. 2022. DOI: https://doi.org/10.1038/s41386-021-00978-8
JUNIOR, S. S. D.; GUARNIER, G. F. F.; CARDOSO, I. B. R. et al. Recuperação de Déficit de Memoria Pós-COVID-19: Uma Revisão. Revista de Ciências Biológicas e da Saúde, 2021. Disponível em: https://unignet.com.br/wp-content/uploads/10_RECUPERACAO-DE-DEFICIT-DE-MEMORIA-POS-COVID-19.pdf. Acesso em: 11 out. 2022.
KIM, Y.; BITNA-HA; Kim, SW. et al. Post-acute COVID-19 syndrome in patients after 12 months from COVID-19 infection in Korea. BMC Infectious Diseases, 2022. DOI: 10.1186/s12879-022-07062-6. Disponível em: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-022-07062-6. Acesso em: 11 out. 2022. DOI: https://doi.org/10.1186/s12879-022-07062-6
KLEIN, R.; SOUNG, A.; SISSOKO, C. et al. COVID-19 induces neuroinflammation and loss of hippocampal neurogenesis. Research Square, 2021. DOI: 10.21203/rs.3.rs-1031824/v1. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34729556/. Acesso em: 21 out. 2022. DOI: https://doi.org/10.21203/rs.3.rs-1031824/v1
KOTFIS, K.; WILLIAMS ROBERSON, S., WILSON, J. E. et al. COVID-19: ICU delirium management during SARS-CoV-2 pandemic. Critical Care (London, England), v. 24, 2020. DOI: 10.1186/s13054-020-02882-x. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32345343/. Acesso em: 22 out. 2022. DOI: https://doi.org/10.1186/s13054-020-02882-x
KOYUNCU, O. O.; HOGUE, I. B.; ENQUIST, L. W. Virus infections in the nervous system. Cell Host & Microbe, v. 13, p. 379–393, 2013. DOI: 10.1016/j.chom.2013.03.010. Disponível em: https://pubmed.ncbi.nlm.nih.gov/23601101/. Acesso em: 21 out. 2022. DOI: https://doi.org/10.1016/j.chom.2013.03.010
LAM, R. W.; KENNEDY, S. H.; McINTYRE, R. S.; KHULLAR, A. Cognitive Dysfunction in Major Depressive Disorder: Effects on Psychosocial Functioning and Implications for Treatment. The Canadian Journal of Psychiatry, v. 59, p. 649–654, 2014. DOI: 10.1177/070674371405901206. Disponível em: https://journals.sagepub.com/doi/10.1177/070674371405901206. Acesso em: 11 out. 2022. DOI: https://doi.org/10.1177/070674371405901206
LI, Y. C.; BAI, W. Z., HASHIKAWA, T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. Journal of Medical Virology, v. 92, p. 552–555, 2020. DOI: 10.1002/jmv.25728. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32104915/. Acesso em: 24 out. 2022. DOI: https://doi.org/10.1002/jmv.25728
LIMA, I. N.; YAMAMOTO, C. Y.; LUZ, J. de S.; et al. Perda de memória associada à infecção viral por SARS-CoV-2: Revisão de literatura. Research, Society and Development, [S. l.], v. 11, n. 4, p. e49011427609, 2022. DOI: 10.33448/rsd-v11i4.27609. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/27609. Acesso em: 11 out. 2022. DOI: https://doi.org/10.33448/rsd-v11i4.27609
LOBO, L. A. C.; RIETH, C. E. Saúde mental e Covid-19: uma revisão integrativa da literatura. Saúde em Debate, v. 45, n. 130, p. 885-901, 2021. DOI: 10.1590/0103-1104202113024. Disponível em: https://www.scielo.br/j/sdeb/a/fgXPhXKhrfM9Tyj55Z8djRt. Acesso em: 11 out. 2022. DOI: https://doi.org/10.1590/0103-1104202113024
LU, Y., LI, X., GENG, D. et al. Cerebral Micro-Structural Changes in COVID-19 Patients - An MRI-based 3-month Follow-up Study. EClinicalMedicine, v. 25, 2020. DOI: 10.1016/j.eclinm.2020.100484. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32838240/. Acesso em: 21 out. 2022. DOI: https://doi.org/10.1016/j.eclinm.2020.100484
MACCHI, J.; HERSKOVITZ, J.; SENAN, A.M. et al. The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections. Journal of Neuroimmune Pharmacol, v. 15, p. 359–386, 2020. DOI: 10.1007/s11481-020-09944-5. Disponível em: https://link.springer.com/article/10.1007/s11481-020-09944-5. Acesso em: 11 out. 2022. DOI: https://doi.org/10.1007/s11481-020-09944-5
MAO, L.; JIN, H.; WANG, M., et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurology, v. 77, p. 683–690, 2020. DOI: 10.1001/jamaneurol.2020.1127. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32275288/. Acesso em: 17 out. 2022. DOI: https://doi.org/10.1001/jamaneurol.2020.1127
MARKOWITSCH, H. J.; STANILOIU, A. Amnesic disorders. Lancet (London, England), v. 380, p. 1429–1440, 2012. DOI: 10.1016/S0140-6736(11)61304-4. Disponível em: https://pubmed.ncbi.nlm.nih.gov/22503117/. Acesso em: 01 nov. 2022. DOI: https://doi.org/10.1016/S0140-6736(11)61304-4
MAZZA, M. G.; DE LORENZO, R.; CONTE, C. et al. Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors. Brain, behavior, and immunity, v. 89, p. 594–600. DOI: 10.1016/j.bbi.2020.07.037. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32738287/. Acesso em: 17 out. 2022. DOI: https://doi.org/10.1016/j.bbi.2020.07.037
MIKKELSEN, M. E.; ABRAMOFF, B. COVID-19: evaluation and management of adults following acute viral illness. UpToDate, 2021. Disponível em: https://www.uptodate.com/contents/covid-19-evaluation-and-management-of-adults-with-persistent-symptoms-following-acute-illness-long-covid. Acesso em: 22 out. 2022.
MIKKELSEN, M. E.; CHRISTIE, J. D.; LANKEN, P. N. et al. The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. American Journal of Respiratory and Critical Care Medicine, v. 185, p. 1307–1315, 2012. DOI: 10.1164/rccm.201111-2025OC. Disponível em: https://pubmed.ncbi.nlm.nih.gov/22492988/. Acesso em: 31 out. 2022 DOI: https://doi.org/10.1164/rccm.201111-2025OC
MINER, J. J.; DIAMOND, M. S. Mechanisms of restriction of viral neuroinvasion at the blood-brain barrier. Current Opinion In Immunology, v. 38, p. 18–23, 2016. DOI: 10.1016/j.coi.2015.10.008. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26590675/. Acesso em: 24 out. 2022. DOI: https://doi.org/10.1016/j.coi.2015.10.008
MISKOWIAK K. W., JOHNSEN S., SATTLER S. M. et al. Cognitive impairments four months after COVID-19 hospital discharge: Pattern, severity and association with illness variables. European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology, v. 46, p. 39–48, 2021. DOI: 10.1016/j.euroneuro.2021.03.019. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33823427/. Acesso em: 17 out. 2022. DOI: https://doi.org/10.1016/j.euroneuro.2021.03.019
MUSSA B. M., SRIVASTAVA A., VERBERNE A. J. M. COVID-19 and Neurological Impairment: Hypothalamic Circuits and Beyond. Viruses, v. 13, 2021. DOI: 10.3390/v13030498. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33802995/. Acesso em: 21 out. 2022. DOI: https://doi.org/10.3390/v13030498
NASSERIE, T.; HITTLE, M.; GOODMAN, S. N. Assessment of the Frequency and Variety of Persistent Symptoms Among Patients With COVID-19: A Systematic Review. JAMA Network Open, v. 4, 2021. DOI: 10.1001/jamanetworkopen.2021.11417. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34037731/. Acesso em: 31 out. 2022. DOI: https://doi.org/10.1001/jamanetworkopen.2021.11417
PUN, B. T.; BADENES, R.; HERAS LA CALLE, G. et al. Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study. The Lancet. Respiratory Medicine, v. 9, p. 239-250, 2021. DOI: 10.1016/S2213-2600(20)30552-X. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33428871/. Acesso em: 22 out. 2022.
RAHMAN M. A., ISLAM K., RAHMAN S., ALAMIN M. Neurobiochemical Cross-talk Between COVID-19 and Alzheimer's Disease. Molecular Neurobiology, v. 58, 2021. DOI: 10.1007/s12035-020-02177-w. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33078369/. Acesso em: 22 out. 2022. DOI: https://doi.org/10.1007/s12035-020-02177-w
RIBEIRO, R. P.; MARTINS, J. T.; MARZIALE, M. H. P. et al. O adoecer pelo trabalho na enfermagem: uma revisão integrativa. Revista da Escola de Enfermagem da USP, v. 46, n. 2, p. 495-504, 2012. DOI: 10.1590/S0080-62342012000200031. Disponível em: https://www.scielo.br/j/reeusp/a/4QYBcfLQQyLyptsFmRqbkyS. Acesso em: 11 out. 2022. DOI: https://doi.org/10.1590/S0080-62342012000200031
RITCHIE, K.; CHAN, D.; WATERMEYER, T. The cognitive consequences of the COVID-19 epidemic: collateral damage?. Brain Communications, v. 2, 2020. DOI: 10.1093/braincomms/fcaa069. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314157/. Acesso em: 22 out. 2022. DOI: https://doi.org/10.1093/braincomms/fcaa069
ROMÁN, G. C.; SPENCER, P. S.; REIS, J. et al. The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries. Journal of the Neurological Sciences, v. 414, 2020. DOI: 10.1016/j.jns.2020.116884. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32464367/. Acesso em: 31 out. 2022. DOI: https://doi.org/10.1016/j.jns.2020.116884
TAKAO, M.; OHIRA, M. (2022). Neurological post-acute sequelae of SARS-CoV-2 infection. Psychiatry and Clinical Neurosciences, 2022. DOI: 10.1111/pcn.13481. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36148558/. Acesso em: 11 out. 2022.
TAQUET, M.; SILLET, R.; ZHU, L. et al. Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients. The Lancet. Psychiatry, v. 9, p. 815–827. DOI: 10.1016/S2215-0366(22)00260-7. Disponível em: https://pubmed.ncbi.nlm.nih.gov/35987197/. Acesso em: 31 out. 2022. DOI: https://doi.org/10.1016/S2215-0366(22)00260-7
TROYER, E. A.; KOHN, J. N.; HONG, S. Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms. Brain, behavior, and immunity, v. 87, p. 34–39, 2020. DOI: 10.1016/j.bbi.2020.04.027. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32298803/. Acesso em: 31 out. 2022. DOI: https://doi.org/10.1016/j.bbi.2020.04.027
VALENZANO, A.; SCARINCI, A.; MONDA, V. et al. The Social Brain and Emotional Contagion: COVID-19 Effects. Medicina (Kaunas, Lithuania), v. 56, 2020. DOI: 10.3390/medicina56120640. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33255569/. Acesso em: 21 out. 2022. DOI: https://doi.org/10.3390/medicina56120640
VOIRIOT, G.; OUALHA, M.; PIERRE, A. et al. Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges. Annals Of Intensive Care, v. 12, 2022. DOI: 10.1186/s13613-022-01038-0. Disponível em: https://pubmed.ncbi.nlm.nih.gov/35779142/. Acesso em: 31 out. 2022. DOI: https://doi.org/10.1186/s13613-022-01038-0
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Revista Master - Ensino, Pesquisa e Extensão
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Política para Periódicos de Acesso Livre
Autores que publicam nesta revista concordam com os seguintes termos:
a) A licença desses direitos autorais abrange o direito exclusivo da Revista Master - Ensino, Pesquisa e Extensão para reproduzir, publicar e distribuir o artigo,
nacional e internacionalmente, incluindo reimpressões, traduções, reproduções fotográficas, microformas, formulários eletrônicos (offline, on-line) ou qualquer outra reprodução de natureza similar.
b) O (s) autor (es) aprovam que o manuscrito não pode ser retirado ou reenviado para qualquer outro Jornal/Revista enquanto a avaliação pelos pares estiver em andamento. Após aprovado o manuscrito, um autor pode auto-arquivar uma versão de seu artigo em seu próprio site e/ou em seu repositório institucional.
c) O (s) autor (es) declaram que são integralmente responsáveis pela totalidade do conteúdo da contribuição e que a Revista Master - Ensino, Pesquisa e Extensão e o corpo editorial da Revista Científica do estão expressamente isentos de qualquer responsabilidade sobre o conteúdo do artigo, métodos, técnicas e resultados de sua pesquisa, tendo, assim, finalidade meramente informativa e educativa.
d) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
