Vitiligo: study of pathophysiology and immune response

Authors

  • Mariana Silva de Muzio Gripp CENTRO UNIVERSITÁRIO IMEPAC ARAGUARI
  • Mateus Carrijo Santos CENTRO UNIVERSITÁRIO IMEPAC ARAGUARI
  • Ana Clara Abrahão Melo CENTRO UNIVERSITÁRIO IMEPAC ARAGUARI https://orcid.org/0000-0002-3394-6930
  • Yaêko Matuda Magalhães CENTRO UNIVERSITÁRIO IMEPAC ARAGUARI
  • Hugo França Queiroz CENTRO UNIVERSITÁRIO IMEPAC ARAGUARI
  • Marcus D'Lucca Carioca CENTRO UNIVERSITÁRIO IMEPAC ARAGUARI
  • Otávio Lopes Barbaresco CENTRO UNIVERSITÁRIO IMEPAC ARAGUARI
  • Lucivânia Marques Pacheco

DOI:

https://doi.org/10.47224/revistamaster.v6i12.172

Keywords:

Vitiligo, Pathophysiology, Immunology, Autoimmune

Abstract

Vitiligo is a micropigmentation of skin tissues caused by the destruction of melanocytes, which affects approximately 1% of the world population. The etiology is unknown, but there are theories that explain the situation: immunological, cytotoxic and neural. The main evidence is related to immunological aspects. Objective: To present the pathophysiology of vitiligo and explore the response mechanism of the patient's immune system. Methodology: A bibliographic survey was carried out on SciELO, Google Scholar and Lilac's databases, between 2008-2014, with the descriptors vitiligo, treatment, diagnosis, depigmentation, melanin, autoimmune, pathophysiology, immunology and humans and, after applying inclusion and exclusion criteria 4 surveys were selected. Results: The analysis of the articles showed that the cause is mainly related to genetic, autoimmune, biochemical, viral and environmental factors. He also pointed out that 20 to 30% of patients with vitiligo have positive family occurrences for the disease. In addition, there is a relationship between skin depigmentation and the presence of specific antibodies in the blood serum, which are: thyroid peroxidase in greater prevalence than anti-nuclear antibodies. Conclusion: The most accepted cause is related to the immune response. However, there is a need to increase new articles related to pathophysiology, since the number found was scarce.

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References

ARAÚJO, O. Vitiligo: fisiopatologia, diagnóstico e tratamento. 2016. 50 f. Trabalho de Conclusão de Curso (ciências farmacêuticas), Centro Universitário Luterano de Palmas (CEULP/ULBRA), Palmas, 2016.
INGORDO, V et al. Circulating autoantibodies and autoimmune comorbidities in vitiligo patients: a multicenter Italian study. Dermatology, v. 228, n.3, p. 240–249, 2014.
KASUMAGIC-HALILOVIC, E et al. Vitiligo and autoimmunity. Med Arch, v. 67, n. 2, p. 91–93, 2013.
NAI, G. A. et al. Imuno-histoquímica para o diagnóstico precoce de vitiligo. Jornal Brasileiro de Patologia e Medicina Laboratorial. v. 44, n. 5, p. 367-373, 2008.

Published

2021-11-04

How to Cite

GRIPP, M. S. de M. .; SANTOS, M. C.; MELO, A. C. A. .; MAGALHÃES, Y. M. .; QUEIROZ, H. F. .; CARIOCA, M. D. .; BARBARESCO, O. L. .; MARQUES PACHECO, L. Vitiligo: study of pathophysiology and immune response. Revista Master - Ensino, Pesquisa e Extensão, [S. l.], v. 6, n. 12, p. 18–20, 2021. DOI: 10.47224/revistamaster.v6i12.172. Disponível em: https://revistamaster.imepac.edu.br/RM/article/view/172. Acesso em: 30 oct. 2024.

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